ASN Live Update 2010; Is fibrosis harmful? in the intact nephron?

At the plenary session at ASN 2010, Dr. Kriz discussed about fibrosis and is that really harmful to the intact nephron? studies showed that it is not! at least in the early stages.
The key points are
1. Progressive renal failure is based on the progressive loss of nephrons and they all loose nephrons independently.
2. Fibrosis is an advanced stage that has an autonomous drestruction of so far unaffected nephron remains an open question