Concept Map: Sickle Cell and the Kidney

 

Concept Map: Sickle Cell Disease and the Kidney

CONSULT ROUNDS: Glomerular disease with Sickle cell disease

From the largest case series of 18 biopsies
The four most common histology in the glomeruli were

FSGS ( 39%)-- any variant--likely due to hypoxia
MPGN(28%)- not sure if this was immuglobulin only or complement only- but likely null IF making omre likely a chronic TMA
TMA( 17%)
Sickle cell glomerulopathy( 17%)

Here is a nice recent review by Karl Nath( editor in chief of JASN)
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4701210/