Drugs in Osteoporosis in CKD: Orson Moe, MD
1. Anti reabsorptive agents: Kill osteoclasts
Bisphosphanates: work fast, blasts slow down and increase bone quantity but turnover is reduced ( so not a good option for someone with Adynamic bone disease). Usually contraindicated in GFR<30. If you have CKD stage 3 and you have a low DEXA and aydnamic bone disease and get a bisphosphanate, now hyou have zero turnover more fractures.
HRT/SERM: inhibit osteoclast proliferation and function, again leading to low turnover
Calcitonin: doesn’t completely kill osteoclast, the balance of blasts is maintained. Not widely used though.
Anti RANKL M ab: data on CKD lacking and transplant no experience
2. Osteo anabolic agents
Pth: pulse pth, data on CKD not very strong
Strontium, IGF-1 and other s in pipeline
Best agents in CKD: Calcicum, Vitamin D, Exercise and dietary acid lowering.
- ► 2020 (32)
- ► 2019 (42)
- ► 2018 (57)
- ► 2017 (52)
- ► 2016 (45)
- ► 2015 (63)
- ► 2014 (95)
- ► 2013 (133)
- ► 2012 (201)
- ► 2011 (370)
- CONSULT ROUNDS: Propofol Infusion Syndrome
- Sirolimus - The negative aspects
- Nephsap review: Fluids Electrolytes
- CLINICAL CASE 29, ANSWERS AND SUMMARY
- ASN 2010 - Live update: "Onco Nephrology"
- Video: The Treatment of Resistant Nephrotic Syndro...
- ASN 2010 Live Update - Late Breaking Trials
- Dialysis Access Atlas from Fistula First. Check it...
- Access Educational Tool
- ASN 2010 Live Update- Nephrology Education
- ASN 2010 Live Update - hyponatremia
- ASN 2010 Live Update - Transplantation in the Elderly
- ASN 2010 Live Update- KDIGO guidelines for HTN
- ASN Live Update 2010: Drugs in Osteoporosis and CKD
- ASN Live Update 2010; CKD -BMD or Osteoporosis
- ASN Live Update 2010: Osteoporosis, steroid induce...
- ASN Live Update 2010; Is fibrosis harmful? in the ...
- ASN Live Update 2010: Glomerular Damage leading to...
- ASN Live Update 2010: VEGF and Diabetic Nephropathy
- ASN Live Update 2010: VEGF and the podocyte
- ASN Live Update 2010: Cirrhosis and the Kidney
- ASN Live updates from nephrology on demand
- ASN Live Update 2010:when do to combined liver-kid...
- Diet and CKD - Historical Interest
- The Kidney Transplant in HIV patients- the NEJM study
- ASN 2010 Live Update - Careers in nephrology
- What Dialysis Modality you would want? Survey
- Presentations from the Prevention in Renal Disease...
- Medicine for residents: urinalysis in rhabdomyolysis
- CKD videos from The Visual MD
- IN THE NEWS- DENSE DEPOSIT DISEASE AND MGUS?
- New Website
- JOURNAL CLUB: FGF 23 and UREMIC parathyroid glands
- Medicine for residents: Hyperkalemia with beta blo...
- CONSULT ROUNDS: Risk Factors of Contrast Induced N...
- The Tips to Keep Your Kidney Healthy- Old Folk Son...
- IN THE NEWS--> DIALYSIS PROPUBLICA ARTICLE
- TOPIC DISCUSSION: "Onco" Nephrology
- Medicine for residents: Chlorthalidone.......what ...
- 5 Major Effects of High Blood Pressure - 3D Medica...
- History of Nephrology: Hepatitis outbreaks run thr...
- IN THE NEWS- ANTI FACTOR H antibodies and TMA
- Tubulointerstitial Nephritis
- CONSULT ROUNDS: UREMIC LUNG
- CLINICAL CASE 28, ANSWERS AND SUMMARY
- Quiz 8 answers
- TOPIC DISCUSSION: Secondary Oxalate Nephropathy
- Nephrogenic Systemic Fibrosis-An Evolving Disease ...
- Top Transplant Programs "by volume" in 2009, check...
- Nephsap review: AKI and ICU Nephrology
- ▼ November (51)