Wild Nephrology explored again

Soil samples from this locale provided material for WHAT renal immunosuppressive agent?

This is rapamune( sirolimus).  Most of you got this one. It was discovered by Brazilian researchers as a prodcut of bacterium streptomyces hygroscopius in the soils of the Easter Island also known as Rapa Nui.

The US President who died of Bright's disease is Chester A Arthur.
He was the 21st US President. ( 1881-85)

Image Quiz: Wild Nephrology Part 5

Only US president to die from renal failure (Bright’s disease).

Wild Nephrology Explored

Last week we had three questions regarding plants that were related to Nephrology.

Wild Nephrology Part 1: Name the " Electrolyte disorder" most commonly associated with this plant.

This is FloxGlove, the plant that is where we get digoxin from. The best-known species is the common foxglove, Digitalis purpurea. This biennial plant has vivid flowers which range in color from various purple tints through various shades of light gray, and to purely white.
Digoxin inhibits Na-K ATPase as a results K remains outside the cells and results in hyperkalemia. Since K and digoxin compete for the same pump, hypokalemia can make digoxin toxicity worse. So, both Kalemias are associated with this agent- one that worsens the toxicity and other as a result of toxicity. 
 http://circ.ahajournals.org/content/48/4/830.full.pdf



Wild Nephrology Part 2: Name the "electrolyte disorder" associated with this plant.

This is Opium Poppy and the most likely disorder is hyponatremia as a result of extreme nausea. 








Wild Nephrology Part 3: The drug from this plant has to be dose adjusted in CKD. Name the plant and the drug

This is Pacific Yew(Taxus brevifolia). The chemotherapy drug paclitaxel (taxol), used in breast, ovarian, and lung cancer treatment, is derived from Taxus brevifolia. Dose adjustment is needed for this chemotherapy in CKD patients. There are no FDA-approved labeling guidelines for dosage adjustment in patients with renal impairment. Experts recommend no dosage adjustment necessary for adults with Cl_cr<50 mL/minute but many do adjust. 

Image Quiz: Wild Nephrology Part 4

Soil samples from this locale provided material for WHAT renal immunosuppressive agent.

Image Quiz: Wild Nephrology Part 3

The drug from this plant has to be dose adjusted in CKD. Name the plant and the drug

Image Quiz: Wild Nephrology Part 2

Name the "electrolyte disorder" associated with this plant.

New Nephrology Journal with cases to learn from images

The Open Urology and Nephrology Journal(TOUNJ) has an entire section on "Learning from Images"- all open access.

http://benthamscience.com/open/tounj/articles/V005/28TOUNJ.pdf

http://benthamscience.com/open/tounj/articles/V005/33TOUNJ.pdf

http://benthamscience.com/open/tounj/articles/V005/48TOUNJ.pdf

http://benthamscience.com/open/tounj/articles/V005/50TOUNJ.pdf

History of Nephrology: Old Dialysis Machines

Image Quiz: What causes this color?

What is your differential diagnosis for "green urine"?

The Kidney Doctor: IMAGE OF THE MONTH

The Kidney Doctor: IMAGE OF THE MONTH: This is a patient with edema and an albumin creatinine ratio of 5.2. What cast is this? Answer for August's image of the month: B. Cys...