A nice plenary session at ASN 2010 by Dr. William Kriz discussed the ways glomerular damage leads to Tubular interstitial damage?
Two theories exist: Leak theory and loss of albumin and other proteins can be damaging to the tubules
Data on this theory not that great.
second theory: As glomruli get damaged, eventually the damage gets closer to glomuler tubular juunction and that leads to spreading of misdirected filtrate and cell proliferation and that leads to intra tubular obstruction and degeneration of tubules.
Leads to IFTA in glomerular disease...
Interesting concepts and worth exploring more on this...
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