When we look at different angiotensin receptor blockers. All of them have different half lives and apparently different excretion means.
Which ARB is longest acting:- Telmisartan has the longest half life of 24 hours; followed by Irbesartan which is 15 hours, Olmesartan is 13 hours and then comes valsartan at 9 hours, eprosartan at 7hours, candesartan at 4hours, and losartan is the shortest acting at 2 hours.
Which ARB is cleared by the liver? All of them are. Valsartan, Irbesartan and Eprosartan are >80 cleared by liver. Olmesartan, losartan and candesartan have significant renal clearance( >30%) hence making it a tough choice in someone with CKD perhaps?
Which ARB gets affected by diet? Only valsartan can be modified due to diet, rest are not.
Which ARB is most bioavailable? Irbesartan is the most at 70%, rest of them are around 30-40%
All ARBS are protein bound.
- ► 2018 (55)
- ► 2017 (52)
- ► 2016 (45)
- ► 2015 (63)
- ► 2014 (95)
- ► 2013 (133)
- ► 2012 (201)
- ► 2011 (370)
- Nephsap review: AKI and ICU Nephrology
- Minimal Change Disease
- IN THE NEWS- CALMAG TRIAL
- TOPIC DISCUSSION: Management of DKA in hemodialysi...
- Nephrology Fellows do better with online training!...
- IN THE NEWS- Barbershop BP management is better th...
- Outcomes of kidney transplantation from HCV positi...
- IN THE NEWS- Permeability Factor and FSGS
- Salivary Prograf levels
- U 002 Nierentransplantation / kidney transplant
- TOPIC DISCUSSION: Green Urine
- FGF-23 and PTH and Bone Disease post transplant
- IN THE NEWS- Bilirubin might be protective
- Aspergilloma in the transplant kidney
- Racial Disparities in CKD, a presentation
- CONSULT ROUNDS: Page Kidney
- Renal Fellow Network: Pancreas transplant pearls
- TOPIC DISCUSSION: Different ARBS
- TOPIC DISCUSSION: Urinary Diversions
- Wait list and desensitization?
- CLINICAL CASE 27, ANSWERS and SUMMARY
- Sirolimus and Male Fertility
- IN THE NEWS:- Tiger on Dialysis
- IN THE NEWS:- Cardiorenal syndrome or renocardiac ...
- NEJM Case
- CONSULT ROUNDS: renal disease
- TOPIC DISCUSSION: Chronic Hyponatremia
- Quiz 7 Answers
- New Transplant Information website
- CONSULT ROUNDS: Free water excretion
- TOPIC DISCUSSION: SECONDARY VS PRIMARY FSGS
- TOPIC DISCUSSION: Maintenance of Metabolic Alkalos...
- REJECTION and TOLERANCE
- KIDNEY WEBSITES IN my languages!
- Renal Fellow Network: Key to angiotensin formation...
- JOURNAL CLUB: AASK TRIAL 2010
- TOPIC DISCUSSION: An uncommon consult:-OHSS!
- IN THE NEWS- Nephrology Workfore
- Basic concepts in Immunology
- Role Playing exercise in Transplant Education
- TOPIC DISCUSSION
- CLINICAL CASE 26 , ANSWER and SUMMARY
- ▼ October (42)