When you encounter a hypokalemia with metabolic alkalsosis that is normo-tensive, there are very few diagnosis to consider: Diuretic use, abuse or diuretic like syndromes ( namely Bartter Syndrome(BS) and Gitelman's Syndrome(GS))
Take home points:
1. There are 4 different types of Bartter syndrome( basically anyway the cell in the thick ascending loop of henle can be affected in absorption of Na-Cl.)- a loop diuretic like effect
Bartter syndrome I - Defects in the Na-K-2Cl transporter
Bartter syndrome II - Defects in the apical potassium channel, caused by mutations in the ROMK1 gen
Bartter syndrome III - This is due to mutations in the CLCNKB gene leading to Cl channel problem in the basolateral surface.
Bartter syndrome IV - This is due to mutations in the CLCNKA gene. Again affecting the Cl-K exchange in the basolateral surface.
2. A fifth variant might occur that is AD as opposed to being AR (the above 4 variants) that affects the Ca sensing receptor in the basolateral surface.
3. Most of the above lead to hypocalcemia and hypercalciuria.
4. Gitelman's syndrome is a loss-of-function mutations in the SLC12A3 gene that codes for the thiazide-sensitive Na-Cl cotransporter in the distal convoluted tubule. This leads to a more pronounced hypomagnesemia and hypocalciuria compared to the prior. This is a more common entity in adults
5. An interesting way to differentiate the two would be to use diuretics to observe the Urinary Cl and Na concentrations. A patient with GS, when given Thiazides will have no major change as that channel is already not working but will have an increase in Urinary CL and Na when given a Loop diuretic. Vice versa, the effect of loop of a patient with BS will show no changes but when given a thiazide will have increase urinary CL and Na.
6. Treatment is usually using K sparing agents like Amiloride, aldosterone antagonists or NSAIDs.
7. Chronic Hypokalemia can lead to hypokalemic related Nephropathy and ESRD.
8. Renin and Aldosterone levels are usually high in these cases.
Few good references regarding the use of diuretics to make diagnosis
- ► 2018 (27)
- ► 2017 (52)
- ► 2016 (45)
- ► 2015 (63)
- ► 2014 (95)
- ► 2013 (133)
- ► 2012 (201)
- ► 2011 (370)
- Educational Video
- CMV infection in Kidney Transplantation
- The Online Transplant Center: CMV infection in Kid...
- Early Dialysis
- Polycystic Kidney Disease
- IN THE NEWS: LIVER induced erythropoietin producti...
- JOURNAL CLUB: RITUXIVAS Trial
- Interferon Gamma use in fungal infections in trans...
- DIURETICS PRESENTATION
- IN THE NEWS- Hyperkalemia review
- Quiz 4 Answers
- The Kidney is not silent
- CLINICAL CASE 24, ANSWERS and SUMMARY
- The Online Transplant Center
- Post Transplant Lymphoproliferative Disorder (PTLD...
- B cell and long term graft function
- Renal Fellow Network: Hot peppers for hypertension...
- CONSULT ROUNDS: LOW POTASSIUM STORY!
- IN THE NEWS: MIDODRINE
- CONSULT ROUNDS: ANCA negative Pauci-Immune Cresent...
- Transplantatation of two kidneys in marginal donor...
- The Micro RNA blog
- History of Nephrology: A nice image of The father ...
- CONSULT ROUNDS: Resp Alkalosis
- BKV viral protein-1 mRNA in urinary cells
- TOPIC DISCUSSION: Plasma Pheresis and Renal Diseas...
- IN THE NEWS: DETECTIVE NEPHRON's NEXT VENTURE
- CLINICAL CASE 23 , ANSWER and SUMMARY
- TOPIC DISCUSSION: Hyperkalemia due to cell shifts?...
- Educational Link on nephrology
- CLINICAL CASE 22, ANSWERS AND SUMMARY
- Medical Innovation
- CONSULT ROUNDS: Management of BEER POTAMANIA
- The Online Transplant Center: Low Donor Kidney Wei...
- Low Donor Kidney Weight ? Does it matter?
- Renal Biopsy simulation
- Reno vascular Hypertension View more presentation...
- Post transplant TMA, revisiting Atypical HUS
- TOPIC DISCUSSION: 25-OH Vitamin D and ESRD
- IN THE NEWS:- MAYO CLINIC AND SOCIAL MEDIA
- ▼ August (40)