Monday, January 10, 2011
IN THE NEWS --> Cytoresistance and the kidney
In the recent CJASN issue of Jan 2011, a clinical paper of this entity was reported in the post BMT patients with renal injury. We know that Bone marrow nephropathy exists and there was multiple causes for it. Close to >3000 cases were reviewed and the groups with >25% drop in GFR were assessed and then the absolute loss of GFR was noted. Interestingly, they noted that the higher the baseline eGFR, the greater the risk and severity of subsequent loss of renal function with statistical P value. So if you had lower GFR to start with, there was "cytoresistance" to further renal damage.
This is an interesting concept. This is a retrospective review, only bone marrow transplant patients, they get a lot of immunomodulatory agents, including radiation, T cell depletion sometimes, and the eGFR was only one value after a year. When immunemodulatory agents are involved, don't know how we can really evaluate this concept. Perhaps a broader renal injury ( cardiac surgery, ATN sepsis) should be evaluate to see if this concept holds.
- ► 2019 (42)
- ► 2018 (57)
- ► 2017 (52)
- ► 2016 (45)
- ► 2015 (63)
- ► 2014 (95)
- ► 2013 (133)
- ► 2012 (201)
- Pregnancy in Chronic Kidney Disease
- CONSULT ROUNDS: Cetuximab therapy and wasting synd...
- TOPIC DISCUSSION: LEAD and the KIDNEY
- Vitamin D- NEJM Review 2011
- IN THE NEWS- TPA vs Heparin- NEJM Study
- Kidney Disease: Racial Disparities from the Inside...
- Dabigatran, and what about its use in Nephrology a...
- The Transplant Web
- TOPIC DISCUSSION: Blood Urea Nitrogen ( BUN)
- Diabetic Nephropathy Video on You tube
- 2011 Guest Lecture Series (Part 1 of 2): Gerald A...
- TOPIC DISCUSSION: Thiazides and Hyponatremia
- IN THE NEWS--> Storytelling and Hypertension
- Fibrosis with Inflammation at One Year Predicts Tr...
- NSLIJ - Innate B Cell in Humans that Protects Agai...
- IN THE NEWS-->AngII and Metabolic Syndrome
- TOPIC DISCUSSION: Magnesium for pre eclampsia?
- IN THE NEWS:- THE BOLDE Study
- TOPIC DISCUSSION: Paraneoplastic Glomerulopathy
- Informing the Debate: Rates of Kidney Transplantat...
- History of Nephrology: The Korean War 1950-3
- TOPIC DISCUSSION: Cryoglobulin Classification Made...
- CLINICAL CASE 31, ANSWER and SUMMARY
- Quiz 9 Answers
- HISTORY LESSON- Scribner Shunt
- IN THE NEWS --> Cytoresistance and the kidney
- PD University = HD university
- Medicine for residents: urinary calcium and renal ...
- Life After Renal Fellowship Survey Results
- Bisphosphonate Therapy in CKD and ESRD patients
- CONSULT ROUNDS: Amyloidosis vs Light Chain Deposit...
- The Study of Heart and Renal Protection — SHARP Tr...
- Can Alcohol Consumption be protective post transpl...
- DID YOU KNOW? Extra renal Podocyte like systems?
- TOPIC DISCUSSION: Low or negative Anion gap!
- ▼ January (35)
- ► 2010 (461)