Tuesday, January 4, 2011

DID YOU KNOW? Extra renal Podocyte like systems?

Besides the kidney, where else does a well designed filtration barrier exist in our body? This area lacks podocytes but produces a filtrate that is also virtually free of plasma proteins.
Its the choroid plexus. The sieving coefficient of the plexus is similar to that of the renal glomerulus. So do patients leak protein in the CSF in proteinuric diseases? In a small cohort study of diabetic patients that protein concentrations where increased in the CSF with diabetes duration.

Take a look at these references:
Image source: Penn state

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