Thursday, June 17, 2010

Topic Discussion: Primary vs Secondary Membranous

What things on pathology can help differentiate primary from secondary membranous GN?
Usually its secondary when there are:
1. mesangial deposits along with membranous and intramembranous deposits
2. full house pattern on IF
3. tubular reticular inclusions present on EM
4. irregularity of thickness of BM

Again these are subtle findings and its all in the right clinical context.

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