Sunday, June 6, 2010

B cell signature and Tolerance

Recently we discussed B regulatory cells. Before one could think, a study in JCI discusses this very topic of B cell signature in tolerant renal transplant recipients.  This is the largest cohort of tolerant renal patients and when they did compared gene expression profiles, they found that the predominant Cell was a B cell that was regulating the maturing of most B cells. IL -10 was also significant.  This B cell signature was associated with upregulation of CD20 mRNA in urine sediment cells and elevated numbers of peripheral blood naive and transitional B cells in tolerant participants compared with those receiving immunosuppression. 
Finally, B cells are making a mark, just lagging slightly behind the T cells.
Hmmm. is Rituximab all good then???


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