Friday, June 18, 2010

Panel Reactive Antibody? how do you calculate?

We always talk about the PRA is 0% and 50% and so forth. How is that calculated?
Well, there is a calculator. The CPRA estimates the percentage of donors that would be incompatible with the candidate, based on the candidate's unacceptable antigens.
Check out

When you go to the calculator, you enter all the unacceptable antigens for the patient and it spits out a value. 

This has been validated by OPTN/UNOS Histocompatibility subcommittee. Then based on the center, the decision is made.  This algorithm is a more accurate measure of sensitization because it accounts for both Class I and II antigens
You can learn more about it at the UNOS website

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