Tuesday, April 27, 2010
1. What is senescence: some cells drop out completely, some persist in damaged form (atrophic tubular cells) and others remain as senescent cells that show limited function and are unable to proliferate.
2. These senescent cells compromise the integrity of the tissue as a result and this is part of the process of aging.
3. The cells have altered morphology, greater heterogeneity, expression of associated ß-galactosidase (SA-ß-GAL) & accumulation of lipofuscin granules.
4. Several candidate genes p21 and p16 have been also reported to play a role in senescence
5. A special case for a possible interaction of underlying renal senescence imposed stresses might be the poor performance of transplanted kidneys from older donors, particularly cadaveric donors. Poorer graft survival might be secondary due to older kidneys with increased senescent cells. These showed increased P16 activity and increased IF/TA.
6. Studies have shown that certain things stress and cause accelerated senescence. Hypertension is one of those things.
7. Telomere knock out mice showed less of chronic changes and less senescent cells. Perhaps a future pathway to NOT age????
Some interesting stuff. Few references below:
Image source: cartoonstock.com
- ► 2019 (42)
- ► 2018 (57)
- ► 2017 (52)
- ► 2016 (45)
- ► 2015 (63)
- ► 2014 (95)
- ► 2013 (133)
- ► 2012 (201)
- ► 2011 (370)
- JOURNAL CLUB: Metabolic Acidosis and improving GFR...
- The Online Transplant Center: Kidney Biopsy in Hea...
- Kidney Biopsy in Heart Transplant Candidates?
- TOPIC DISCUSSION: Cellular Senescence and Renal Ag...
- CLINICAL CASE 12
- CLINICAL CASE 11
- IN THE NEWS ---> Vancomycin and the kidney
- TOPIC DISCUSSION: Smoking and Kidney Disease
- The Online Transplant Center: Dual Liver and Kidne...
- The Online Transplant Center: HIV and the Kidney T...
- The Online Transplant Center: Obesity and Kidney T...
- Dual Liver and Kidney Transplantations
- HIV and the Kidney Transplant
- Obesity and Kidney Transplantation
- In the News: ASN website for Renal Fellows
- TOPIC DISCUSSION: Adolescents and Disease
- TOPIC DISCUSSION: Why do AVG and AVF get stenosis?...
- NKF reports
- CONSULT ROUNDS
- TOPIC DISCUSSION: Asymptomatic Hyponatremia
- IN THE NEWS- RENAL ANGINA SYNDROME
- CLINICAL CASE 10, ANSWER AND SUMMARY
- TOPIC DISCUSSION: PHOSPHATE BINDERS
- TOPIC DISCUSSION: A rare case of statin induced rh...
- IN THE NEWS: GLOSEN Study
- IN THE NEWS: Dialysis Time
- TOPIC DISCUSSION: Albuminuria and Proteinuria
- The Online Transplant Center: Antibody Mediated Re...
- Antibody Mediated Rejection Review
- The Online Transplant Center: Bone marrow transpla...
- Bone marrow transplantation and solid organs
- IN THE NEWS: Tyrosine Kinase Inhibitors and CKD
- IN THE NEWS- MORE NEPHROLOGY CONSULTS
- ▼ April (33)