Thursday, July 21, 2011

T regulatory Cells: A short review

T regulatory cells have now come out and made a splash in the transplant world but also in the immunology and glomerular disease world.  Treg are usually CD4+, CD25+, CTLA4+.
A common misconception is that all are Foxp3 positive.  
There are many types of Tregs.
Natural kind that do express Foxp3 and CD25 and they usually are IL-2 dependent
Induced Tregs are induced in the periphery and can express Foxp3 but after development
Regulatory Tregs do not express Foxp3 and CD25. They depend on IL-10 on development.

IL-10 has always been associated with regulatory function.
Now given above information, immunology always is evolving and who knows what will be new in 2011.

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