Sunday, April 17, 2011

IN THE NEWS -MDR-1 polymorphisms in steroid resistance

Genetics has entered Nephrology with a bang. More and more genetic linkages have allowed for new discoveries to shed light on many glomerular and non glomerular diseases. A recent study in NDT describes the MDR-1 gene expression and P-glycoprotein function with nephrotic syndrome.  This is in >200 children study, but sheds an important point. Steroid resistant vs. steroid sensitive.  It showed that patients with nephrotic syndrome carrying homozygous mutants of single nucleotide polymorphism (SNP) G2677T/A are prone to develop steroid resistance.

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