Which one of these drugs is associated with Drug Induced Lupus or vasculitis?
Anti-double stranded DNA antibodies are typically absent in drug-induced lupus due to procainamide, hydralazine, and isoniazid, such antibodies are associated with drug-induced disease with other agents, particularly with interferon-alfa and anti-TNF agents. Drug-induced ANCA are sometimes associated with necrotizing vasculitis. Anti-tumor necrosis factor alpha therapy with infliximab, adalimumab, and etanercept has been associated with the development of positive test results for ANA and anti DSdNA.
The renal disease in drug-induced lupus is most often due to a necrotizing glomerulonephritis with little or no immune complex deposition. Usually this is Anti MPO or p ANCA or atypical ANCA( classically in hydralazine). These patients may also have anti-double-stranded DNA antibodies when renal involvement is seen.
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