A recent study in AJT March 2010 issue evaluated what happens to patients after they get a kidney transplant in terms of their nephrogenic systemic fibrosis disease. They studied 17 patients retrospectively.
Nine of 11 transplanted patients had NSF pre transplant and 2 had post transplant DGF and then NSF.
6 dialysis patients with NSF were also studied. They followed these patients for 35 months for post transplant patients and 9 months for dialysis patients. Baseline GFR for transplant patients were 42ml.min.
NSF only improved in 55% of transplant patients and 50% of non transplanted patients. Of the 6 patients of the 11 total transplanted patients, 4 had partial remission and 2 had complete remission of NSF.
It seems that they summarize that transplant or no transplant, 50% had some remission of NSF. So it doesn't seem that transplantation changed outcomes for their NSF.
This is important as this is the largest study of NSF in transplant patients I found so far. Hopefully a more prospective study might be more helpful. In general, i think we are going to see less and less of this disease as we are avoiding gadolinium based MRIs in many of our CKD and post transplant CKD patients.
Monday, March 22, 2010
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