Here's a simple way to differentiate from smoldering or inactive Myeloma from active( borrowed from our Heme/onc doctors)
C alcemia (hyper)
R enal failure
B ony mets and pain
I nfections or immunoparesis(is defined as a reduction (below the lower normal limit) in the levels of 1 or 2 immunoglobulin (Ig), with respect to the values of the corresponding uninvolved Ig.)
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