Latest offerings in NEJM highlight nephrology articles:
One of them is comparing ultrafiltration to diuretic use in cardio renal syndrome(CARRESS-HF).
Interestingly, ultrafiltration performed inferiorly compared to a catered diuretic regimen in a randomized controlled trial. Does it end the role of UF? Or is SCUF still a consideration. An editorial attached still says slow and steady might be preferred.
ADPKD and treatment with aquretic treatment is the next major article. The TEMPO trial showed this using tolvaptan. Can this drug show promise in protecting renal function in ADPKD.
EVOLVE trial looked at cinacalcet in ESRD patients in a randomized trial and evaluated cardiac endpoints and found shockingly negative results.
ALTITUDE trial evaluated adding aliskiren to other renin angi inhibitors in DMII for cardio renal end points and found harm and no significant benefit.
3 negative trials
1 positive trial
Evidence based medicine keeps knocking off physiology based medicine in Nephrology.
- ► 2020 (21)
- ► 2019 (42)
- ► 2018 (57)
- ► 2017 (52)
- ► 2016 (45)
- ► 2015 (63)
- ► 2014 (95)
- ► 2013 (133)
- ANP and AKI
- IN the news: The CANDY Study
- Uncomplicated Urinary Tract infections: New guidel...
- IN THE NEWS: SuPAR and FSGS more data revealed
- Free light chain induced Acute Kidney Injury- mech...
- Clinical Case 64: Answers and Summary
- Costs of Care education initiative? Where do nephr...
- 20 Years of Uptodate.com
- Secondary Causes of Cryoglobulinemia associated G...
- Donor evaluation and follow ups- a new ruling!
- IN THE NEWS: Nephrology NEJM showcase
- First Annual ASN Fellows in Training Bowl( FIT Bowl)
- Are Nephrologists and their patients ready for Nat...
- Topic Discussion: Cholemic Nephrosis
- eAJKD and NOD: ASN 2012
- Clinical Case 63: Answers and Summary
- ASN Podcasts
- History of hope
- ▼ November (18)
- ► 2011 (370)
- ► 2010 (461)