Besides phosphate metabolism, what other functions does the klotho gene have associations with?
Klotho actually means "who spun the thread of life". The klotho knockout mouse has the following finding:
faster aging, hypogonadism, growth retardation, atrophy of skin, cognition impairment.
The transgenic Klotho mice have increase in lifespan. FGF 23 def mice are similar to Klotho def mice and hence the relation came about. Some studies show that it is the phosphate retention that causes extensive aging like features. It is not surprising that it is the phosphate that really makes the big difference in CKD and dialysis patients.
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