Membranous GN can be idiopathic or secondary. Idiopathic has been associated with IgG4 subtype noted on IF which activates complement alternatively. The secondary forms usually are either IgG1, 2 or 3 and don't activate complement alternate pathway but do classical pathway. When lupus or hepatitis patients have membranous, the IF usually shows IgG1,2 or 3 and possibly full house and TRIs as well( in lupus). The patients with MPGN have granular glomerular deposits of all four IgG subclasses, with a predominance of IgGl and IgG3. These data suggest that the IgG4 subclass may play an important role in the pathogenesis of idiopathic membranous.
Another distinguishing feature at least now available is the antibodies to the human phospholipase
A2 receptor (PLA2R) found in many patients with idiopathic membranous.
- ► 2019 (42)
- ► 2018 (57)
- ► 2017 (52)
- ► 2016 (45)
- ► 2015 (63)
- ► 2014 (95)
- ► 2013 (133)
- ► 2012 (201)
- Geriatric Nephrology
- TOPIC DISCUSSION: Ageusia and ACEI/ARBS
- Nephrology Quiz at UKidney.com
- Disorders of Sodium & Water Balance: A mathematic...
- IN THE NEWS- Idiopathic Membranous GN and HLA-DQA1
- Skin cancer and Transplants
- TOPIC DISCUSSION: Is Veno-occlusive disease associ...
- JOURNAL CLUB: ESCAPE TRIAL
- Nephrology Anagrams
- TOPIC DISCUSSION: Renal Vein Pressures and Cardio ...
- World Kidney day
- CLINICAL CASE 33, ANSWER AND SUMMARY(IMAGE QUIZ)
- Suggest and Vote for New Ideas in Nephrology
- Risk factors for post transplant Hypertension
- TOPIC DISCUSSION: Pseudohyperphosphatemia
- TOPIC DISCUSSION: Hypercalcemia of Malignancy
- JOURNAL CLUB: BELATACEPT and Transplantation
- TOPIC DISCUSSION: Lactic acidosis and Dialysis?
- Male Fertility and Transplantation
- TOPIC DISCUSSION: Membranous and Class Type IgG
- Renal Blog in finalist for Best Medical Blog( Clin...
- TOPIC DISCUSSION: Spontaneous Perinephric Hemorrhage
- Nephsap review: Transplantation
- Acute Kidney Injury in Cancer Patients
- CLINICAL CASE 32, ANSWERS AND SUMMARY
- ▼ February (25)
- ► 2010 (461)