Old article, but nice review:
-90% mortality of TTP if untreated
-Pentad not needed for dxn, only MAHA and low plts along with appropriate clinical setting
-Childhood HUS with diarrheal prodrome (Shiga toxin/E.Coli O157:H7) treatment is only supportive care and antiobiotics should be withheld intially unless toxic/bacteremic since it may release more Shiga toxin and exacerbate the HUS
-ADAMTS13 deficiency (cleaving ulVWF) NOT seen in diarrheal prodrome HUS
-Neuro symtpoms more with TTP, renal more with HUS
-Distinguish TMA due to other disorders incl malignant HTN and autoimmune disorders
-LDH levels will be sky high often, schistos, polychromatophilic red cells, indirect bili, neg direct Coombs
-Acute flares may or may not have low levels of ADAMTS13, so cannot go by this, it only tells you risk of relapse
-PEX!!!! If delay, can use plasma infusion but not as effective. Steroids maybe
-Causes: Idiopathic (rare to have renal manifestations), pregnancy, autoimmune d/o, diarrheal prodrome (HUS), immune mediated and dose dependant drug toxicity, HST (TMA usually limited to kidney, unlikely to benefit from PEX)
-PEX works even if no severe ADAMTS13 deficiency
- ► 2019 (36)
- ► 2018 (57)
- ► 2017 (52)
- ► 2016 (45)
- ► 2015 (63)
- ► 2014 (95)
- ► 2013 (133)
- ► 2012 (201)
- ► 2011 (370)
- Virtual Grand Rounds in Nephrology- E nephrology
- ASN's review on the ESRD bundling
- TOPIC DISCUSSION: EFFECT OF PROTEINURIA on combina...
- Poem from Pediatric Nephrologist
- TOPIC DISCUSSION: ACE induce angioedema replaced b...
- Nephsap review: Chronic Kidney Disease : CKD patie...
- Nephsap review: Chronic Kidney Disease: Troponin T...
- Bundled Payment for ESRD
- 2010 North American Dialysis and Transplantation (...
- Hematuria and Donation?
- TOPIC DISCUSSION: Do Peritoneal Dialysis patients ...
- Renal Fellow Network: Deciphering the pathologists...
- TOPIC DISCUSSION: TIDAL PD
- TOPIC DISCUSSION: DEXA SCAN in TRANSPLANT PATIENTS...
- CLINICAL CASE 21, ANSWERS AND SUMMARY
- Plagiarism In Application Essays????
- Micro RNAs and Transplantation
- IN THE NEWS: Anabolic Steroids and FSGS
- CLINICAL CASE 20, ANSWERS AND SUMMARY
- Pediatrics Grand rounds continue
- CONSULT ROUNDS: Severe Pre eclampsia
- Milk and CKD
- Transplant/Immunology Quiz 3 answers
- Rituximab and Cyclophosphamide: A Tale of Two Trea...
- CONSULT ROUNDS: HUS/TTP During Pregnancy
- IN THE NEWS: FACTOR H REPLETION in Atypical HUS
- Leflunomide and liver failure
- TOPIC DISCUSSION: Gadolinium and NSF- How to image...
- Lupus Nephritis Post Transplant
- Why do Internal Medicine Residents Choose Nephrolo...
- TOPIC DISCUSSION: TTP/HUS
- CONSULT ROUND: Hypercalcemia and Lithium
- CONSULT ROUND: ATHEROEMBOLIC DISEASE
- CONSULT ROUNDS:Rare and Interesting Cause of Hyper...
- TOPIC DISCUSSION: URR and Kt/V
- Organ Trading Discussion
- Dietary Management of Hypertension
- Chronic Dialysis: Now or Later?
- Photopheresis therapy for renal allograft rejectio...
- IN THE NEWS --->google as a diagnostician
- Live Donor Nephrectomy with vaginal extraction
- CLINICAL CASE 19, ANSWER AND SUMMARY
- IN THE NEWS- HYPOMAGNESEMIA AND PPI?
- JOB MARKET for RENAL FELLOWS
- Nephron Power: NYSN Fellows Boot camp
- NYSN Fellows Boot camp
- TOPIC DISCUSSION: captopril and stones?
- Topic Discussion: D-Lactate vs D-lactic acid
- ▼ July (48)