Thursday, May 30, 2013

CONSULT ROUNDS: Rising BUN only

Three common causes of rising BUN without serum crt rise are: ( in setting of normal GFR)

1. Steroid use
2. GI bleed
3. Tetracycline use

The third one is interesting. In 1972, experiments showed that rise in BUN was seen in some patients that got tetracyclines. The reason was due to anti anabolic effects of these class of drugs on amino acid incorportation into protein. Next time, you give democlocycline for SIADH, watch the BUN

1 comment:

  1. Another important and common cause of isolated BUN rise is TPN ( especially in ICU patients ) an needs to be differentiated from other causes like dehydration

    ReplyDelete

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