Three common causes of rising BUN without serum crt rise are: ( in setting of normal GFR)
1. Steroid use
2. GI bleed
3. Tetracycline use
The third one is interesting. In 1972, experiments showed that rise in BUN was seen in some patients that got tetracyclines. The reason was due to anti anabolic effects of these class of drugs on amino acid incorportation into protein. Next time, you give democlocycline for SIADH, watch the BUN
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