Last year, a prospective study was published in JAMA suggesting that having a history of kidney stones as an independent risk factor for cardiac disease (CHD).
What is the mechanism?
1. Perhaps there is a unknown metabolic state that is both a risk factor for stones and CHD
2. The stone might increase some other factor that we don’t know that leads to CHD
3. There might be some other confounding factor we haven’t found.
Why Women: - No clear explanation can be found, perhaps an unknown factor that is not clear yet.
Major limitations: Self reported questionnaire, stone analysis not clear, most patients were white and not many blacks, Asians or Hispanics.
Very fascinating study but leaves us with more questions than answers. At this point, would not make any major statements based on this observational study re risk of cardiac disease and stones.