Nephrologists often use a rule of thumb that the urine protein: creatinine ratio—a unitless number—approximates the 24-h protein excretion in grams. This approximation is based on the assumption that the 24-h urine creatinine excretion is approximately 1000 mg.
There are few instances when this might not be true and hence in those cases the Total Protein/creatinine ratio can be misleading and give false results.
1. AKI:- As there is decreased clearance of creatinine, the total protein/crt ratio can have now a falsely lower denominator and hence leading to a larger ratio. This can possibly mistake some cases of just pure AKI with AKI now with nephrotic syndrome.
2. Increased Muscle mass: In cases of gross increase in muscle mass, the ratio can grossly underestimate the total ratio.
3. Severe CKD
A nice reference is in CJASN from 2009
- ► 2018 (55)
- ► 2017 (52)
- ► 2016 (45)
- ► 2015 (63)
- ► 2014 (95)
- Topic Discussion: Genetic Diabetes Insipidus
- Pathology and Nephrology: A combined force!
- Adult cancer survivors and risk of kidney disease?...
- In the NEWS: Acute tubular damage from synthetic c...
- Hibernating bears and Nephrology
- Detective Nephron's next venture
- Pitfalls of urinary protein/crt ratio
- PitFalls in GFR: Pregnancy
- Concept Map: Hypophosphatemia
- ▼ February (9)
- ► 2012 (201)
- ► 2011 (370)
- ► 2010 (461)