Myeloma cast nephropathy is classically a tubular interstitial disease. Glomerular diseases in myeloma can be classified as either with organized deposits or amorphous deposits.
1. Organized deposits;- AL amyloidosis ( Usually lambda), Type I and II cyroglobulinemia ( Usually kappa), Immunotactoid GN ( Usually kappa)
2. Amorphous deposits: MIDD ( LCDD, HCDD, LHCDD) - usually kappa if light chain, Proliferative GN with non organized monoclonal Ig deposits ( kappa)
Just another way to think of these patterns in myeloma.
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