Differential diagnosis for nodular glomerulosclerosis on kidney biopsy
The differential is vast but a good way to differentiate is via IF staining
If Immuno is positive, either monoclonal or polyclonal:
Think:- Monoclonal IF:- MPGN, or paraprotein related disease such as LCDD or amyloidosis
If polyclonal IF:- Immunotactoid, fibrillary,cryoglobulinemia and other organized deposits seen in fibronectin GN
If Immuno is negative( more common):
Chronic ischemic disease or hypoxia
Smoking associated nodular sclerosis and or related to metabolic syndrome
Check out a recent quiz on eAJKD on this topic.
Check out the concept map on this to simplify.
- ► 2020 (25)
- ► 2019 (42)
- ► 2018 (57)
- ► 2017 (52)
- ► 2016 (45)
- ► 2015 (63)
- ► 2014 (95)
- ► 2013 (133)
- Student mentorship : early on with KDSAP
- In the News: Is Normal Saline good enough?
- Nodular glomerulosclerosis
- Interesting fact: Turtle urine
- Quiz to determine elderly death risk on dialysis
- Concept Map: Hypophosphatemia
- In The News: Basic research in nephrology?
- Topic Discussion: Anemia mechanisms
- Topic Discussion: Glomerular disease in Myeloma
- Topic Discussion: Myeloma and the kidney- why?
- ▼ October (10)
- ► 2011 (370)
- ► 2010 (461)