Monday, September 17, 2012

In the News: The POWER of HERCULES

Renal artery stenosis has taken a story of the classic pendulum swinging.  Studies that were observational in the 1990s suggested benefit in stenting and angioplasty as a treatment of modality. Recent trials such as STAR and ASTRAL ( largest to date) have shown no significant benefit in interventional interventions for atherosclerotic renal artery stenosis(ARAS).

While CORAL is still underway, here comes HERCULES.  This is a large prospective multi-center single arm study of patients with significant RAS and uncontrolled HTN. This is in contrast to prior trails that had less sicker patients. Most were at least on 2 agents and 75% on ACEI or ARBS. The procedure related complications were only 1.5% compared to prior studies suggesting as high as 17%.  The results suggested drop in SBP significantly at 9 months, low in stent restenosis rate and complication rates.
While this is a positive study in terms of intervention- the fact that it is a single arm trial, makes it a major limitation.  HERCULES has limitations too. CORAL is still awaited.

Regardless- check out the full trial at Catheterization and cardiovascular interventions. 

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