Tuesday, July 28, 2015

Consult Rounds: Ifosfamide Toxicity

Ifosfamide induced renal damage comes in 6 flavors. The toxic agent is metabolite chloroacetaldehyde rather than the parent drug to the tubular cells of the kidney.
1.     Pure hypophosphatemia – this is due to direct proximal damage
2.     Fanconi syndrome
3.     Pure renal potassium wasting syndrome leading to hypokalemia
4.     ATN
5.     Distal RTA
6.     Nephrogenic Diabetes insipidus

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