PEMETREXED IS KNOWN TO CAUSE RENAL TOXICITY IN SOME CASES. WHAT IS THE PATHOLOGY FINDING USUALLY?
The classic finding with this nephrotoxic agent is Tubular and interstitial disease.
Pemetrexed is an antifolate agent approved for the treatment of advanced lung cancer.A recent publication in American Journal of Kidney Diseases discusses potential nephrotoxicity of this drug. Kidney biopsy specimens showed tubulointerstitial injury with tubular simplification, shrinkage, loss of brush border, and tubular atrophy in a more advanced case. eAJKD did an exclusive video blog with the authors Dr. Ilya Glezerman( Renal service, Memorial Sloan Kettering Cancer Center, NY) and Dr.Surya Seshan( Chief of Renal Pathology, Professor of Pathology, Weill Cornell Medical Center, NY). Check out the complete article at AJKD.