MTOR inhibitors are widely used in many GU cancers and in kidney transplantations. mTOR inhibitors are known to cause proteinuria and many cases of biopsy proven FSGS, collapsing GN and TMA. There is always a risk of AIN with any drug. Of note, recently, in a manuscript in the Ann of Oncology, Izzedine et al present 4 cases of biopsy proven ATN from mTOR inhibitors.
A kidney biopsy showed acute tubular necrosis (ATN) with prominent tubular dysfunction. Withdrawal of the drug leads to a rapid recovery in two cases. However, a fixed renal dysfunction was noted in the other two cases, one of which will remained dialysis-dependent. Two cases used A TORC1/TORC2 inhibitor and one case of everolimus and one of temsirolimus.
A toxicity to watch out for all transplant and onco-nephrologists.
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