Presentations from the Prevention in Renal Disease conference by Ukidney.com

Check out a 2 page presentations on http://ukidney.com/prevention-in-renal-disease-meeting-2010
about the recent prevention in renal disease meeting in Toronto 2010.

Medicine for residents: urinalysis in rhabdomyolysis

Medicine for residents: urinalysis in rhabdomyolysis: "Urinalysis is an important part of the evaluation of any renal disorder.It is very simple, easy to perform and gives quick and valuable info..."

CKD videos from The Visual MD

http://www.thevisualmd.com/health_centers/urological_health/chronic_kidney_disease

This is an interesting 15 videos on CKD using lifestyle changes and epigenetic ( way you think) change your body.

IN THE NEWS- DENSE DEPOSIT DISEASE AND MGUS?

The connection of Dense Deposit Disease and MGUS is unique and recently investigators explored this in a series of patients at the Mayo Clinic.
All 10 patients had a serum monoclonal spike of IgG k or lambda and then had a biopsy proven dense deposit disease.
A presumptive pathophysiology is mentioned: Perhaps the MGUS leads to activation of formation of Antibodies of Factor H or regulators of complement activators.  This can be compounded by H402 Allele of Factor H that is making it second hit for DDD.  This leads to dysregulated complement activation and a full blown C3 glomerulopathy and dense deposit disease.
Most of these 10 patients either had a low alternative pathway , autoantibody to factor H or heterozygosity to H402 allele of Factor H.  MGUS is associated with this phenomenon or just another bystander and nothing to do with DDD, is not clear.  4 of their 10 patients became ESRD, 2 are CKD and remaining are a recent diagnosis. So its unclear if this DDD is behaving like the classic DDD with quick progression to ESRD.

Interesting observation and something to keep in mind.
Image source: Imperial College, London, UK
References:

http://www.ncbi.nlm.nih.gov/pubmed/20832153
http://www.ncbi.nlm.nih.gov/pubmed/20185597
http://www.ncbi.nlm.nih.gov/pubmed/20852386

New Website

Check out this excellent blog on Fixing the current system of dialysis

http://www.fixdialysis.com/

JOURNAL CLUB: FGF 23 and UREMIC parathyroid glands

Journal Club: FGF23 Fails to Inhibit Uremic Parathyroid Glands By Dr. Hitesh Patni

View more presentations from Nephrology, NSLIJ.

Medicine for residents: Hyperkalemia with beta blockers!

Medicine for residents: Hyperkalemia with beta blockers!: "I recently had a Chronic kidney diesease patient on low dose Ramipril with a stable potassium level for many months, got admitted to the hos..."