Friday, June 18, 2010

Panel Reactive Antibody? how do you calculate?

We always talk about the PRA is 0% and 50% and so forth. How is that calculated?
Well, there is a calculator. The CPRA estimates the percentage of donors that would be incompatible with the candidate, based on the candidate's unacceptable antigens.
Check out http://www.unos.org/resources/frm_cpra_calculator.asp


When you go to the calculator, you enter all the unacceptable antigens for the patient and it spits out a value. 

This has been validated by OPTN/UNOS Histocompatibility subcommittee. Then based on the center, the decision is made.  This algorithm is a more accurate measure of sensitization because it accounts for both Class I and II antigens
You can learn more about it at the UNOS website

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