NK cell
neoplasms have a wide range of clinical, morphologic, and immunophenotypic
characteristics. Aggressive NK cell leukemia usually
affects young patients in their 20-30s with equal sex incidence and shows a
rapidly progressive clinical course. Often they don’t respond well to chemotherapy
and prognosis is poor.
Kidney
involvement in these cancers is rare but here is what I found?
One case
report of a collapsing FSGS published in AJKD in 2011. Initially, in this
case, the first biopsy was read as FSGS NOS and then a repeat one had
collapsing glomerulopathy.
Another recent case
series describes cases of renal diseases seen with all types of non-Hodgkin’s
lymphoma. They describe 20 cases. T/NK cell lymphoma was
in 4 cases. 2 of the 4 cases had crescentic GN, 1 had minimal change disease
and 1 had infiltrative disease.
A very early description
of minimal change disease has been described in a case report in 1980s of a
large granular cell lymphoma.
So in summary, NK cell neoplasms likely are
related to cause some glomerular involvement-likely podocytopathies such as minimal
change to FSGS. Cases of crescentic GN have also been described.
