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Showing posts with label myeloma. Show all posts
Showing posts with label myeloma. Show all posts
Thursday, July 20, 2023

In the NEWs- New Myeloma Working Group Update-- Myeloma related renal disease management

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 An important guideline/recommendation was published in Lancet thismonth . This is an evidence based summary by the International Myeloma W...
Wednesday, May 1, 2019

Consult Rounds: Heavy Chain Deposition Disease

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Heavy-chain deposition disease (HCDD) is the least common non-organized monoclonal immunoglobulin deposition disease (MIDD), with close ...
Thursday, February 8, 2018

MGRS and MGUS- the 1/3-2/3 rule of pathology in the kidney?

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When someone has MGUS, what is the true incidence of kidney disease? – this has not been answered. An old study from AJKD in 2003 did help ...
Sunday, September 25, 2016

Targeted therapies and the Kidney

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Novel targeted anti-cancer therapies have resulted in improvement in patient survival compared to standard chemotherapy. Renal toxicities ...
Sunday, February 21, 2016

Monoclonal Gammopathy and end organ damage ( Skin, Nerves, Cornea and more):- it’s not just the kidney.

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While MGUS and Kidney disease is now a finding well described in the literature, why not other organs? It is quite possible that th...
Tuesday, January 20, 2015

Topic Discussion: Proximal Tubulopathies with monoclonal light chains

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Proximal tubule is a commonly involved part of the kidney in myeloma.  Classically, they are noted more with light chains compared to h...
Sunday, September 21, 2014

TOPIC DISCUSSION: Crystalglobulinemia and prarproteins and the kidney

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Crystalglobulin induced nephropathy is a known complication of paraproteinemias.  A recent review In JASN focus...
Friday, August 29, 2014

In the NEWS: LCDD without proteinuria: A challenge for nephrologist

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Classically Light chain deposition disease(LCDD) presents with proteinuria ( almost in the nephrotic range). A recent article in NDT look...
Friday, April 12, 2013

Concept Map: Monoclonal Gammopathy of Renal Significance (MGRS)

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1 comment:
Tuesday, April 9, 2013

MGRS: We need to think a new way!

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Many times we have come across monoclonal deposition in the kidney of Ig and there is no bone marrow or blood findings to suggest malignancy...
Monday, December 3, 2012

MGRS: Monoclonal Gammopathy of RENAL SIGNIFICANCE: A new name for an old entity to define treatment

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What happens with we find renal pathology findings and they confirm a monoclonal strain of B cell clone. A bone marrow is...
Friday, November 23, 2012

Free light chain induced Acute Kidney Injury- mechanisms revealed

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A recent review of the pathophysiology of light chain damage in the kidney suggests some novel findings. 1. Apoptosis is a feature of e...
Tuesday, November 6, 2012

Clinical Case 63: Answers and Summary

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MGUS HAS NOW SOME SIGNIFICANCE IN THE KIDNEY AND MONOCLONAL GAMMOPATHY OF RENAL SIGNIFICANCE(MGRS) IS EMERGING. REGARDING THE NATURAL HIS...
Wednesday, October 3, 2012

Topic Discussion: Glomerular disease in Myeloma

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Myeloma cast nephropathy is classically a tubular interstitial disease. Glomerular diseases in myeloma can  be classified as either with org...
Monday, October 1, 2012

Topic Discussion: Myeloma and the kidney- why?

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Why do the free light chains affect the kidney? How does the injury happen? Research in this matter has revealed significant insight. The ...
Tuesday, September 27, 2011

IN THE NEWS:- Renal Cell Cancer Research Update 2011

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Renal Cell Cancer(RCC) has been in the limelight recently. Two recent studies provided some interesting links.  In a large prospective study...
Friday, June 10, 2011

TOPIC DISCUSSION: Light chains and the Kidney- traveling the nephron

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Light chains can be toxic to the kidney when they are over produced. The types of pathology one finds are: Cast Nephropathy( usually lig...
Thursday, April 28, 2011

TOPIC DISCUSSION: Vascular Amyloidosis and the Kidney

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Most of the pathology in the kidney from AL Amyloidosis is glomerular in origin. Cases have been noted of pure selective amyloid deposition ...