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Thursday, February 23, 2012

CLINICAL CASE 52: ANSWERS and SUMMARY


TRUE OR FALSE: SEVERE METABOLIC OR RESPIRATORY ALKALOSIS CAN LEAD TO AN ANION GAP METABOLIC ACIDOSIS.

True 60%
False 40%

Severe alkalemia can cause an increase in anion gap.  Alkalemia leads to glycolysis in the liver and a mild lactic acidosis. In severe volume contracted state, the anion gap can be seen with change in valence of circulating proteins to preserve extracellular volume.  
A prior post had discussed this as well. 

See the references below:

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