Which of these options are treatment options for management of methotrexate nephrotoxicity?
4 (14%)
|
8 (28%)
|
14 (50%)
|
13 (46%)
|
5 (17%)
|
3 (10%)
|
4 (14%)
|
3 (10%)
|
MTX ( methotrexate) is a chemo agent that is nephrotoxic. At high doses, it and its metabolite can accumulate and can cause acute tubular injury. Dosages higher than 1000mg/m2 are what is associated with renal damage. Most oncologists use prevention strategies with hydration and leucovorin to help combat this side effect.
What helps decrease MTX levels:- all the above listed are right answers. The glucarpidase is a new agent that is experimental but has shown some promise.
What helps decrease MTX levels:- all the above listed are right answers. The glucarpidase is a new agent that is experimental but has shown some promise.
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