tag:blogger.com,1999:blog-5872673930112727345.post1006118704526571999..comments2024-03-29T03:49:52.282-04:00Comments on Nephron Power: Hyponatremia Guidelines Part 4Kenar D Jhaveri( kidney 007)http://www.blogger.com/profile/08654527832183917798noreply@blogger.comBlogger1125tag:blogger.com,1999:blog-5872673930112727345.post-38153249570680297012014-08-15T02:06:22.907-04:002014-08-15T02:06:22.907-04:00"If mild, suggest against treatment with the ..."If mild, suggest against treatment with the sole aim to increase the Na". I disagree since recent research suggest that mild hyponatremia is associated with increased mortality and morbidity including increased risk for falls, fractures, attention deficits, gait disturbances and osteoporosis. I think these goes beyond an statistical association ... there is biologic plausability: people with hyponatremia develop brain glutamate deficiency. Glutamate is one of the solutes astrocytes eliminate in an effort to restore intracellular volume down to normal. Glutamate is an essential neurotransmiter for cerebellar function. Also, osteoporosis has been found in animals with chronic hyponatremia apparently caused by osteoclast activation and in some cases driven by ADH.Dr. Helbert Rondonhttps://www.blogger.com/profile/04527191513403619201noreply@blogger.com